Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17377883 | 0.74 | CHRNB2 (0.47) | CHRNB2CHRNA4DRD2KCNH2LMNA | |
| SCHEMBL5015324 | 0.70 | CHRNB2 (0.68) | CHRNB2CHRNA4DRD2TRPV6CHRM2 | |
| SCHEMBL11201872 | 0.70 | GAA (0.53) | LMNATSHRKDM4EALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL61401 | 0.69 | CHRNB2 (0.66) | CHRNB2CHRNA4DRD2TRPV6CHRM2 | |
| SCHEMBL23028620 | 0.68 | CHRNB2 (0.64) | CHRNB2CHRNA4TRPV6KDM4EALDH1A1 | |
| SCHEMBL29508484 | 0.68 | CHRNB2 (0.64) | CHRNB2CHRNA4TRPV6KDM4EALDH1A1 | |
| SCHEMBL16026435 | 0.68 | CHRNB2 (0.85) | CHRNB2CHRNA4DRD2TRPV6KDM4E | |
| SCHEMBL12424619 | 0.67 | CHRNB2 (0.68) | CHRNB2CHRNA4TRPV6KDM4EALDH1A1 | |
| SCHEMBL30574692 | 0.67 | CHRNB2 (0.68) | CHRNB2CHRNA4TRPV6KDM4EALDH1A1 | |
| SCHEMBL8306431 | 0.67 | CHRNB2 (0.72) | CHRNB2CHRNA4DRD2TRPV6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797099-A1 | PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS | Epix Delaware, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034511-A1 | PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS | EPIX DELAWARE, INC. (US) | 2006-03-30 | — | — | WO | disclosed |