Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CD38 | P28907 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259230 | 0.88 | BRAF (0.58) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL8256959 | 0.82 | EIF2AK2 (0.62) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL4773624 | 0.82 | EGFR (0.59) | BRAFTNNI3KEGFRCYP1A2CYP3A4 | |
| SCHEMBL8257175 | 0.81 | EIF2AK2 (0.57) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL8256956 | 0.81 | BRAF (0.58) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL8255837 | 0.79 | CSNK2A2 (0.56) | BRAFTNNI3KEGFRCSF1R | |
| SCHEMBL5565783 | 0.79 | EIF2AK2 (0.58) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL8255818 | 0.79 | EGFR (0.58) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL8259233 | 0.78 | ABCG2 (0.57) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL5559096 | 0.77 | BRAF (0.53) | BRAFTNNI3KEGFREIF2AK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | claimed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | claimed |
| WO-2004093812-A2 | COMPOUNDS THAT INDUCE NEURONAL DIFFERENTIATION IN EMBRYONIC STEM CELLS | IRM LLC (BM) | 2004-11-04 | — | — | WO | claimed |
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | FER, ERBB3, FLT3 | BRAF 57/4885TNNI3K 511/4885EGFR 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.