Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 7/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.55 |
| ▸ | TTBK1 | Q5TCY1 | 4/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | NEK4 | P51957 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259230 | 0.87 | BRAF (0.58) | EIF2AK2GSK3BBRAFTNNI3KAHR | |
| SCHEMBL8256959 | 0.82 | EIF2AK2 (0.62) | EIF2AK2GSK3BBRAFTNNI3KTTBK1 | |
| SCHEMBL4773624 | 0.82 | EGFR (0.59) | BRAFTNNI3KTTBK1TTBK2EGFR | |
| SCHEMBL20139118 | 0.81 | EGFR (0.64) | BRAFTNNI3KEGFR | |
| SCHEMBL8255837 | 0.80 | CSNK2A2 (0.56) | BRAFTNNI3KEGFRNPC1RAB9A | |
| SCHEMBL5559435 | 0.79 | BRAF (0.51) | EIF2AK2GSK3BBRAFTNNI3KAHR | |
| SCHEMBL8257175 | 0.78 | EIF2AK2 (0.57) | EIF2AK2GSK3BBRAFTNNI3KTTBK1 | |
| SCHEMBL8256956 | 0.78 | BRAF (0.58) | EIF2AK2GSK3BBRAFTNNI3KTTBK1 | |
| SCHEMBL8255818 | 0.78 | EGFR (0.58) | EIF2AK2GSK3BBRAFTNNI3KAHR | |
| SCHEMBL8259233 | 0.77 | ABCG2 (0.57) | EIF2AK2GSK3BBRAFTNNI3KEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | claimed |
| WO-2004093812-A2 | COMPOUNDS THAT INDUCE NEURONAL DIFFERENTIATION IN EMBRYONIC STEM CELLS | IRM LLC (BM) | 2004-11-04 | — | — | WO | claimed |
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
| WO-2004093812-A2 | COMPOUNDS THAT INDUCE NEURONAL DIFFERENTIATION IN EMBRYONIC STEM CELLS | IRM LLC (BM) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | FER, ERBB3, FLT3 | EIF2AK2 2201/4885GSK3B 6/4885BRAF 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.