Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23326744 | 0.80 | HSD17B10 (0.33) | ADORA2AADORA2BADORA1SELEVCAM1 | |
| SCHEMBL29861403 | 0.80 | HSD17B10 (0.33) | ADORA2AADORA2BADORA1SELEVCAM1 | |
| SCHEMBL12410481 | 0.79 | SELE (0.35) | SELEVCAM1SLC22A12PDE4APDE4B | |
| SCHEMBL17148436 | 0.78 | SELE (0.34) | SELEVCAM1SLC22A12PDE4APDE4B | |
| SCHEMBL21273016 | 0.75 | MAPT (0.48) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL3705661 | 0.74 | PDE2A (0.33) | ADORA2AADORA1 | |
| SCHEMBL22658512 | 0.74 | SLC22A12 (0.34) | SELEVCAM1SLC22A12PDE4APDE4B | |
| SCHEMBL25456980 | 0.73 | ADORA2A (0.31) | ADORA2AADORA1ALDH1A1MAPTHTT | |
| SCHEMBL23326642 | 0.73 | EGFR (0.35) | ADORA2AADORA2BADORA1SELEVCAM1 | |
| SCHEMBL24672007 | 0.73 | SLC22A12 (0.39) | SELEVCAM1SLC22A12ALDH1A1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230148450-A9 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. | 2023-05-11 | — | — | US | disclosed |
| CN-113767100-A | Bicyclic heteroaryl compounds and uses thereof | 锐新医药公司 | 2021-12-07 | — | — | CN | disclosed |
| US-7968536-B2 | Heterocyclic compounds useful as RAF kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968536-B2 | Heterocyclic compounds useful as RAF kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-06-28 | — | — | US | disclosed |
| WO-2009006404-A2 | HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| US-20090005359-A1 | Heterocyclic Compounds Useful as RAF Kinase Inhibitors | SUNESIS PHARMACEUTICALS, INC (US) | 2009-01-01 | — | — | US | disclosed |
| US-20090005359-A1 | Heterocyclic Compounds Useful as RAF Kinase Inhibitors | SUNESIS PHARMACEUTICALS, INC (US) | 2009-01-01 | — | — | US | disclosed |
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
| WO-2004093812-A2 | COMPOUNDS THAT INDUCE NEURONAL DIFFERENTIATION IN EMBRYONIC STEM CELLS | IRM LLC (BM) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | FER, ERBB3, FLT3 | ADORA2A 3586/4885ADORA2B 3841/4885ADORA1 3900/4885 |
| US-20230148450-A9 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | SOST, SOS1, SOS2 | ADORA2A 1136/4885ADORA2B 1501/4885ADORA1 1911/4885 |
| US-20090005359-A1 | Heterocyclic Compounds Useful as RAF Kinase Inhibitors | BRAF, RAF1, ARAF | ADORA2A 3787/4885ADORA2B 4597/4885ADORA1 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.