Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560226 | 1.00 | RORC (0.37) | RORCNR1H3NR1H2NR1I2 | |
| SCHEMBL1811564 | 0.88 | MEN1 (0.36) | RORCNR1H3NR1H2 | |
| SCHEMBL1811565 | 0.88 | MEN1 (0.36) | RORCNR1H3NR1H2 | |
| SCHEMBL1810361 | 0.73 | NR1H2 (0.43) | NR1H3NR1H2 | |
| SCHEMBL1812680 | 0.72 | MEN1 (0.36) | RORCNR1H3NR1H2NR1I2 | |
| SCHEMBL1807525 | 0.71 | NR1H3 (0.37) | RORCNR1H3NR1H2NR1I2 | |
| SCHEMBL1811946 | 0.70 | ALDH1A1 (0.44) | NR1H3NR1H2 | |
| SCHEMBL1808071 | 0.69 | KMT2A (0.43) | NR1H3NR1H2 | |
| SCHEMBL1812088 | 0.69 | NR1H2 (0.38) | NR1H3NR1H2 | |
| SCHEMBL1810890 | 0.68 | POLB (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756096-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105791-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |