Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.47 |
| ▸ | FLT4 | P35916 | 9/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | FLT1 | P17948 | 5/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | TEK | Q02763 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565927 | 0.85 | KDM1A (0.54) | KDRPDGFRBFLT4EGFRTEK | |
| SCHEMBL5566618 | 0.83 | KDR (0.61) | KDRPDGFRBFLT4FGFR1FLT1 | |
| SCHEMBL5566432 | 0.81 | KDR (0.44) | KDRPDGFRBFLT4EGFRTEK | |
| SCHEMBL5561051 | 0.80 | FLT4 (0.52) | KDRPDGFRBFLT4FGFR1FLT1 | |
| SCHEMBL5566917 | 0.79 | EGFR (0.49) | KDRPDGFRBFLT4FGFR1FLT1 | |
| SCHEMBL5566455 | 0.79 | EGFR (0.53) | KDREGFRKITSRC | |
| Hydrochloric Acid SCHEMBL5566014 | 0.78 | EGFR (0.48) | KDRPDGFRBFLT4FGFR1FLT1 | |
| SCHEMBL5565868 | 0.77 | KDM1A (0.56) | KDRPDGFRBFLT4FGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL5566986 | 0.76 | KDM1A (0.55) | KDRPDGFRBFLT4FGFR1FLT1 | |
| SCHEMBL5566781 | 0.76 | EGFR (0.50) | KDRPDGFRBFLT4EGFRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | claimed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | claimed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | claimed |
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |