Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.43 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565927 | 0.87 | KDM1A (0.54) | KDRPDGFRAPDGFRBFLT4AURKA | |
| SCHEMBL5566766 | 0.83 | EGFR (0.43) | KDRPDGFRBFLT4AURKATEK | |
| SCHEMBL5566618 | 0.83 | KDR (0.61) | KDRPDGFRAPDGFRBFLT4AURKA | |
| SCHEMBL7876949 | 0.81 | KDR (0.37) | KDRPDGFRAPDGFRBFLT4AURKA | |
| SCHEMBL5560397 | 0.81 | KDR (0.47) | KDRPDGFRAPDGFRBFLT4AURKA | |
| SCHEMBL5561051 | 0.80 | FLT4 (0.52) | KDRPDGFRAPDGFRBFLT4AURKA | |
| SCHEMBL5565868 | 0.79 | KDM1A (0.56) | KDRPDGFRBFLT4FLT3CSF1R | |
| Hydrochloric Acid SCHEMBL5566986 | 0.78 | KDM1A (0.55) | KDRPDGFRBFLT4FLT3CSF1R | |
| SCHEMBL5566781 | 0.78 | EGFR (0.50) | KDRPDGFRBFLT4FLT3CSF1R | |
| SCHEMBL5566455 | 0.77 | EGFR (0.53) | KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |