Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.50 |
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | LCK | P06239 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | KIF5B | P33176 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565868 | 0.92 | KDM1A (0.56) | EGFRKDRLCKRETKIF5B | |
| Hydrochloric Acid SCHEMBL5566986 | 0.91 | KDM1A (0.55) | EGFRKDRLCKRETKIF5B | |
| SCHEMBL5566656 | 0.89 | KDM1A (0.53) | EGFRKDRLCKRETKIF5B | |
| Hydrochloric Acid SCHEMBL5566338 | 0.88 | KDM1A (0.52) | EGFRKDRLCKRETKIF5B | |
| SCHEMBL5565932 | 0.85 | KDR (0.60) | EGFRKDRLCKRETCSF1R | |
| SCHEMBL7884841 | 0.85 | KDM1A (0.41) | EGFRKDRLCKRETKIF5B | |
| SCHEMBL7885709 | 0.85 | KDR (0.53) | EGFRKDRLCKRETCSF1R | |
| SCHEMBL5566917 | 0.84 | EGFR (0.49) | EGFRKDRCSF1RIRAK1IRAK4 | |
| Hydrochloric Acid SCHEMBL5566014 | 0.83 | EGFR (0.48) | EGFRKDRCSF1RIRAK1IRAK4 | |
| SCHEMBL5565918 | 0.83 | SRC (0.57) | EGFRKDRLCKRETMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | claimed |
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |