Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fentonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fentonium SCHEMBL251444 | 0.82 | CHRM2 (0.68) | MEN1KMT2ALMNACHRM2CHRM1 | |
| Fentonium SCHEMBL24584 | 0.81 | BLM (0.69) | MEN1KMT2ALMNACHRM2CHRM1 | |
| Fentonium SCHEMBL30186606 | 0.81 | BLM (0.69) | MEN1KMT2ALMNACHRM2CHRM1 | |
| Fentonium SCHEMBL24583 | 0.81 | BLM (0.69) | MEN1KMT2ALMNACHRM2CHRM1 | |
| Fentonium SCHEMBL13724144 | 0.76 | CHRM1 (0.58) | MEN1KMT2ALMNACHRM2CHRM1 | |
| Benziodarone SCHEMBL31326233 | 0.70 | EYA3 (1.00) | MEN1KMT2AEYA3TTRBIRC5 | |
| Benziodarone SCHEMBL308541 | 0.70 | EYA3 (1.00) | MEN1KMT2AEYA3TTRBIRC5 | |
| Xenytropium SCHEMBL30428452 | 0.70 | CHRM2 (0.71) | MEN1KMT2ALMNACHRM2CHRM1 | |
| Xenytropium SCHEMBL29361010 | 0.70 | CHRM2 (0.71) | MEN1KMT2ALMNACHRM2CHRM1 | |
| SCHEMBL14507225 | 0.69 | CHRM2 (0.80) | MEN1KMT2ALMNACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460995-A4 | TRANSDERMAL TRANSPORT OF COMPOUNDS | VITAL HEALTH SCIENCES PTY LTD (AU) | 2007-11-21 | — | — | EP | disclosed |
| EP-1460995-A1 | TRANSDERMAL TRANSPORT OF COMPOUNDS | Vital Health Sciences Pty Ltd. (AU) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003049774-A1 | TRANSDERMAL TRANSPORT OF COMPOUNDS | VITAL HEALTH SCIENCES PTY LTD (AU) | 2003-06-19 | — | — | WO | disclosed |