Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557122 | 0.87 | SMN1; SMN2 (0.36) | SMN1; SMN2RORCRAB9AL3MBTL1HPGD | |
| SCHEMBL556710 | 0.79 | RXFP2 (0.36) | RAB9ANPC1MAPTTDP1 | |
| SCHEMBL16070080 | 0.76 | NR4A1 (0.45) | SMN1; SMN2TRPV1RAB9AL3MBTL1NPC1 | |
| SCHEMBL16070083 | 0.76 | NR4A1 (0.45) | SMN1; SMN2TRPV1RAB9AL3MBTL1NPC1 | |
| SCHEMBL16070082 | 0.76 | NR4A1 (0.45) | SMN1; SMN2TRPV1RAB9AL3MBTL1NPC1 | |
| SCHEMBL556293 | 0.72 | TSHR (0.35) | TRPV1RORCRAB9ANPC1GAA | |
| SCHEMBL556294 | 0.72 | TSHR (0.35) | TRPV1RORCRAB9ANPC1GAA | |
| SCHEMBL556417 | 0.72 | CA1 (0.37) | SMN1; SMN2L3MBTL1GAAP2RX7GPR139 | |
| SCHEMBL557011 | 0.69 | TSHR (0.41) | SMN1; SMN2ATMRAB9AL3MBTL1HPGD | |
| SCHEMBL21953836 | 0.61 | CES2 (0.52) | SMN1; SMN2RAB9AL3MBTL1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035114-A1 | INHIBITORS OF STAT3 AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035114-A1 | INHIBITORS OF STAT3 AND USES THEREOF | STAT3, JAK2, STAT6 | SMN1; SMN2 4774/4885TRPV1 4141/4885ATM 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.