Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 13/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6454187 | 0.87 | F10 (0.47) | F10MAPTALDH1A1HTTMEN1 | |
| SCHEMBL6454183 | 0.81 | F10 (0.45) | F10MAPTSMN1; SMN2NPC1NFKB1 | |
| SCHEMBL5567162 | 0.78 | FAAH (0.36) | TRPV1FAAHMAPTSMN1; SMN2NPC1 | |
| SCHEMBL5502455 | 0.77 | F10 (0.42) | TRPV1FAAHF10GAA | |
| SCHEMBL5506302 | 0.76 | F10 (0.37) | TRPV1FAAHF10GAAALDH1A1 | |
| SCHEMBL5513037 | 0.76 | F10 (0.37) | TRPV1FAAHF10GAA | |
| SCHEMBL5536648 | 0.75 | F10 (0.38) | TRPV1FAAHF10GAAMAPT | |
| SCHEMBL5509110 | 0.75 | F10 (0.38) | TRPV1FAAHF10GAA | |
| SCHEMBL5532364 | 0.74 | F10 (0.31) | TRPV1FAAHF10MAPTSMN1; SMN2 | |
| SCHEMBL5499237 | 0.74 | F10 (0.36) | TRPV1FAAHF10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748997-A1 | SUBSTITUTED THIOPHENE-2-CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005111013-A1 | SUBSTITUTED THIOPHENE-2-CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |