Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940860 | 0.86 | BRD4 (0.45) | BRD4LRRK2ALDH1A1KMT2ACYP11B1 | |
| SCHEMBL4662880 | 0.83 | BRD4 (0.50) | BRD4LRRK2ALDH1A1SRD5A2KMT2A | |
| SCHEMBL16428100 | 0.78 | STAT3 (0.46) | ALDH1A1SRD5A2KMT2ASRD5A1SMN1; SMN2 | |
| SCHEMBL14521393 | 0.76 | PTGER4 (0.39) | BRD4ALDH1A1SMN1; SMN2STAT3HTT | |
| SCHEMBL1940913 | 0.76 | STING1 (0.40) | BRD4ALDH1A1KMT2ASMN1; SMN2STAT3 | |
| SCHEMBL14521330 | 0.75 | STING1 (0.40) | BRD4ALDH1A1SMN1; SMN2STAT3HTT | |
| SCHEMBL9528588 | 0.75 | L3MBTL1 (0.53) | BRD4ALDH1A1SMN1; SMN2STAT3HTT | |
| SCHEMBL4662927 | 0.74 | BRD4 (0.48) | BRD4LRRK2ALDH1A1SRD5A2SRD5A1 | |
| SCHEMBL30501981 | 0.74 | BRD4 (0.48) | BRD4LRRK2SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL1942913 | 0.74 | GLP1R (0.45) | ALDH1A1SRD5A2KMT2ASRD5A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756067-A1 | 7-SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS INHIBITORS OF GASTRIC ACID SECRETION | Altana Pharma AG (DE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005111000-A1 | 7-SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS INHIBITORS OF GASTRIC ACID SECRETION | ALTANA PHARMA AG (DE) | 2005-11-24 | — | — | WO | disclosed |