Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564752 | 0.88 | EIF2AK2 (0.52) | MEN1KMT2AATMEIF2AK2CSNK2A1 | |
| SCHEMBL5890617 | 0.86 | POLB (0.39) | MEN1KMT2AATMEIF2AK2CSNK2A1 | |
| SCHEMBL5563977 | 0.81 | MAPK10 (0.45) | MEN1KMT2AATMALOX5CREBBP | |
| SCHEMBL5564496 | 0.79 | MEN1 (0.42) | MEN1KMT2AATMCSNK2A1ALOX5 | |
| SCHEMBL5455719 | 0.76 | MAPK13 (0.40) | KMT2AADORA3ADORA2AADORA1RAB9A | |
| SCHEMBL6105305 | 0.76 | EIF2AK2 (0.51) | EIF2AK2GSK3B | |
| SCHEMBL6106995 | 0.75 | EIF2AK2 (0.50) | EIF2AK2GSK3B | |
| SCHEMBL6106606 | 0.75 | EIF2AK2 (0.50) | EIF2AK2GSK3B | |
| SCHEMBL6183539 | 0.75 | GSK3B (0.41) | MEN1KMT2AATMEIF2AK2CSNK2A1 | |
| SCHEMBL5890132 | 0.74 | EIF2AK2 (0.49) | EIF2AK2CCNT1CDK9GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1504004-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | SMITHKLINE BEECHAM CORP (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20050203106-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203106-A1 | Therapeutic compounds | ABCB1, PCSK9, ABCB11 | MEN1 464/4885KMT2A 4598/4885ATM 4594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.