Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564255 | 0.88 | MEN1 (0.41) | EIF2AK2GSK3BMEN1KMT2AATM | |
| SCHEMBL6105305 | 0.87 | EIF2AK2 (0.51) | EIF2AK2MAPK10GSK3BMKNK1CDK5 | |
| SCHEMBL6106995 | 0.86 | EIF2AK2 (0.50) | EIF2AK2MAPK10GSK3BMKNK1CDK5 | |
| SCHEMBL6106606 | 0.86 | EIF2AK2 (0.50) | EIF2AK2MAPK10GSK3BMKNK1CDK5 | |
| SCHEMBL5890132 | 0.85 | EIF2AK2 (0.49) | EIF2AK2MAPK10GSK3B | |
| SCHEMBL6702313 | 0.85 | EIF2AK2 (0.49) | EIF2AK2MAPK10CDK1GSK3BCSNK1D | |
| SCHEMBL5890058 | 0.85 | EIF2AK2 (0.49) | EIF2AK2MAPK10GSK3BCSNK2A1 | |
| SCHEMBL5890754 | 0.85 | EIF2AK2 (0.49) | EIF2AK2MAPK10GSK3BCSNK2A1 | |
| SCHEMBL6108267 | 0.83 | GSK3B (0.51) | EIF2AK2MAPK10GSK3BMKNK1CDK5 | |
| SCHEMBL5453019 | 0.83 | EIF2AK2 (0.50) | EIF2AK2MAPK10CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1504004-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | SMITHKLINE BEECHAM CORP (US) | 2007-06-27 | — | — | EP | claimed |
| US-20050203106-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-09-15 | — | — | US | claimed |
| US-7304068-B2 | Substituted pyrazolo [1,5-A] pyrimidinyls and pharmaceutical uses therefore | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304068-B2 | Substituted pyrazolo [1,5-A] pyrimidinyls and pharmaceutical uses therefore | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-04 | — | — | US | disclosed |
| EP-1504004-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | SMITHKLINE BEECHAM CORP (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20050203106-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203106-A1 | Therapeutic compounds | ABCB1, PCSK9, ABCB11 | EIF2AK2 3499/4885MAPK10 2227/4885CCNB2 1454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.