Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008449 | 0.85 | CHRNB2 (0.58) | CHRNB2CHRNA4KEAP1NFE2L2CHRNB4 | |
| SCHEMBL4701140 | 0.79 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNB4CHRNA3GRM5 | |
| SCHEMBL1985000 | 0.79 | CHRNB2 (0.65) | CHRNB2CHRNA4KEAP1NFE2L2CHRNB4 | |
| SCHEMBL31037156 | 0.79 | CHRNB2 (0.65) | CHRNB2CHRNA4KEAP1NFE2L2CHRNB4 | |
| SCHEMBL16178929 | 0.79 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNB4CHRNA3GRM5 | |
| SCHEMBL5149611 | 0.78 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3GRM5 | |
| Ammonia Solution, Strong SCHEMBL3031537 | 0.77 | CHRNB2 (0.63) | CHRNB2CHRNA4NPC1KEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL10551173 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNB4CHRNA3GRM5 | |
| Hydrochloric Acid SCHEMBL10551171 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNB4CHRNA3GRM5 | |
| Hydrochloric Acid SCHEMBL10551164 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNB4CHRNA3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773808-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010641-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-02-02 | — | — | WO | disclosed |