Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2220449 | 0.79 | HDAC6 (0.47) | KDM4EALDH1A1GAARAB9ACYP1A2 | |
| SCHEMBL29973512 | 0.78 | ALDH1A1 (0.54) | KDM4EALDH1A1GAAELANESMYD3 | |
| SCHEMBL2160307 | 0.78 | PARP1 (0.51) | KDM4EALDH1A1RIPK1MEN1CYP1A2 | |
| SCHEMBL9206481 | 0.76 | ALDH1A1 (0.58) | KDM4EALDH1A1GAAELANESMYD3 | |
| SCHEMBL26856720 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1GAAELANESMYD3 | |
| SCHEMBL14159861 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1GAAELANESMYD3 | |
| SCHEMBL2161057 | 0.74 | KMT2A (0.44) | KDM4EALDH1A1RAB9AMEN1CYP1A2 | |
| SCHEMBL19701397 | 0.74 | SMYD3 (0.51) | KDM4EALDH1A1GAAELANESMYD3 | |
| SCHEMBL21490080 | 0.74 | SMYD3 (0.51) | KDM4EALDH1A1GAAELANESMYD3 | |
| SCHEMBL990359 | 0.73 | KDM4E (0.70) | KDM4EALDH1A1GAARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768960-A1 | SULFONAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006005486-A1 | SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-19 | — | — | WO | disclosed |