Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.51 |
| ▸ | PPARA | Q07869 | 7/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14639529 | 0.88 | PPARG (0.51) | PPARGPPARAL3MBTL1ATMALDH1A1 | |
| SCHEMBL31478930 | 0.85 | PPARG (0.63) | PPARGPPARAMRGPRX4L3MBTL1ATM | |
| SCHEMBL31123647 | 0.81 | L3MBTL1 (0.58) | PPARGPPARAL3MBTL1ALDH1A1POLB | |
| SCHEMBL11274332 | 0.81 | L3MBTL1 (0.58) | PPARGPPARAL3MBTL1ALDH1A1POLB | |
| SCHEMBL5438152 | 0.80 | PPARG (0.53) | PPARGPPARAL3MBTL1ALDH1A1POLB | |
| SCHEMBL12812255 | 0.79 | KDM4E (0.52) | MRGPRX4ALDH1A1KDM4ECFTR | |
| SCHEMBL25685760 | 0.77 | CXCR2 (0.57) | PPARGPPARAL3MBTL1ALDH1A1POLB | |
| SCHEMBL29038826 | 0.77 | MAPT (0.61) | MRGPRX4ALDH1A1GAAKDM4E | |
| SCHEMBL5274330 | 0.75 | KDM4E (0.63) | L3MBTL1ATMALDH1A1GAAPOLB | |
| SCHEMBL5563769 | 0.75 | POLB (0.49) | MRGPRX4ALDH1A1GAAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| US-7119112-B2 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060094721-A9 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2006-05-04 | — | — | US | disclosed |
| US-20040106613-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094721-A9 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | PPARG 4036/4885PPARA 3863/4885MRGPRX4 1534/4885 |
| US-20040106613-A1 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | PPARG 4036/4885PPARA 3863/4885MRGPRX4 1534/4885 |
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | PPARG 4036/4885PPARA 3863/4885MRGPRX4 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.