Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31478923 | 0.85 | POLB (0.59) | POLBMEN1GAAKMT2ACYP3A4 | |
| SCHEMBL10927262 | 0.84 | CFTR (0.48) | POLBRORCMEN1GAAKMT2A | |
| SCHEMBL4912518 | 0.82 | ALDH1A1 (0.53) | POLBMEN1KMT2ARECQLLMNA | |
| SCHEMBL12812255 | 0.78 | KDM4E (0.52) | MEN1KMT2ACYP3A4CYP2C19MRGPRX4 | |
| SCHEMBL7569668 | 0.77 | KMT2A (0.76) | RORCMEN1GAAKMT2ALMNA | |
| SCHEMBL29038826 | 0.76 | MAPT (0.61) | MEN1GAAKMT2ARECQLMRGPRX4 | |
| SCHEMBL5565855 | 0.75 | PPARG (0.51) | POLBGAAMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL7363401 | 0.74 | ALDH1A1 (0.57) | POLBKMT2ALMNACA1CA2 | |
| SCHEMBL28104379 | 0.74 | KAT6A (0.41) | POLBGAAKMT2AMRGPRX4LMNA | |
| SCHEMBL28835149 | 0.72 | MAPT (0.42) | MEN1KMT2ACYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| US-7119112-B2 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| EP-1534259-A4 | SULFONAMIDES AS POTASSIUM CHANNEL BLOCKERS | ICAGEN INC (US) | 2006-10-04 | — | — | EP | disclosed |
| US-20060094721-A9 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2006-05-04 | — | — | US | disclosed |
| EP-1534259-A2 | SULFONAMIDES AS POTASSIUM CHANNEL BLOCKERS | Icagen, Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20040106613-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. | 2004-06-03 | — | — | US | disclosed |
| WO-2004016221-A2 | SULFONAMIDES AS POTASSIUM CHANNEL BLOCKERS | ICAGEN, INC (US) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094721-A9 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | POLB 2287/4885RORC 4684/4885MEN1 2417/4885 |
| US-20040106613-A1 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | POLB 2287/4885RORC 4684/4885MEN1 2417/4885 |
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | POLB 2287/4885RORC 4684/4885MEN1 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.