Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.53 |
| ▸ | FLT4 | P35916 | 9/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.53 |
| ▸ | TEK | Q02763 | 4/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.53 |
| ▸ | AURKA | O14965 | 4/20 | 0.53 |
| ▸ | FLT1 | P17948 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565932 | 0.94 | KDR (0.60) | KDRFLT4PDGFRBTEKAURKB | |
| SCHEMBL5565918 | 0.92 | SRC (0.57) | KDRFLT4PDGFRBTEKAURKB | |
| Hydrochloric Acid SCHEMBL5566627 | 0.91 | SRC (0.56) | KDRFLT4PDGFRBTEKAURKB | |
| SCHEMBL5566618 | 0.87 | KDR (0.61) | KDRFLT4PDGFRBTEKAURKB | |
| SCHEMBL5565868 | 0.85 | KDM1A (0.56) | KDRFLT4PDGFRBFLT1EGFR | |
| SCHEMBL5566781 | 0.85 | EGFR (0.50) | KDRFLT4PDGFRBEGFRRET | |
| SCHEMBL5560704 | 0.85 | KDM1A (0.55) | KDRFLT4PDGFRBTEKAURKB | |
| Hydrochloric Acid SCHEMBL5566986 | 0.84 | KDM1A (0.55) | KDRFLT4PDGFRBFLT1EGFR | |
| SCHEMBL5561123 | 0.84 | EGFR (0.56) | KDRFLT4FLT1EGFRKIT | |
| SCHEMBL5561051 | 0.84 | FLT4 (0.52) | KDRFLT4PDGFRBTEKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |