Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.60 |
| ▸ | FLT4 | P35916 | 10/20 | 0.60 |
| ▸ | TEK | Q02763 | 8/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.60 |
| ▸ | AURKA | O14965 | 7/20 | 0.60 |
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | FLT1 | P17948 | 5/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885709 | 0.94 | KDR (0.53) | KDRFLT4TEKAURKBPDGFRB | |
| SCHEMBL5565918 | 0.93 | SRC (0.57) | KDRFLT4TEKAURKBPDGFRB | |
| SCHEMBL5566618 | 0.92 | KDR (0.61) | KDRFLT4TEKAURKBPDGFRB | |
| Hydrochloric Acid SCHEMBL5566627 | 0.92 | SRC (0.56) | KDRFLT4TEKAURKBPDGFRB | |
| SCHEMBL5565868 | 0.86 | KDM1A (0.56) | KDRFLT4PDGFRBEGFRFLT1 | |
| SCHEMBL5566781 | 0.85 | EGFR (0.50) | KDRFLT4PDGFRBEGFRLCK | |
| SCHEMBL5560704 | 0.85 | KDM1A (0.55) | KDRFLT4TEKAURKBPDGFRB | |
| Hydrochloric Acid SCHEMBL5566986 | 0.85 | KDM1A (0.55) | KDRFLT4PDGFRBEGFRFLT1 | |
| SCHEMBL19258107 | 0.85 | KDR (0.73) | KDRFLT4TEKAURKBPDGFRB | |
| SCHEMBL5561051 | 0.85 | FLT4 (0.52) | KDRFLT4TEKAURKBPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | claimed |
| EP-1299382-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2005-09-21 | — | — | EP | claimed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | claimed |
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |