Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCA | P06881 | 7/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | COMT | P21964 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966281 | 0.94 | CALCA (0.59) | CALCAKDM4EHTTL3MBTL1MAPT | |
| SCHEMBL967391 | 0.92 | CALCA (0.53) | CALCACTSBCACNA1BKDM4EHTT | |
| SCHEMBL965773 | 0.86 | CALCA (0.60) | CALCAKDM4EHTTL3MBTL1MAPT | |
| SCHEMBL966989 | 0.86 | CALCA (0.62) | CALCACACNA1BKDM4EL3MBTL1COMT | |
| SCHEMBL968717 | 0.85 | CALCA (0.51) | CALCAKDM4EHTTL3MBTL1POLB | |
| SCHEMBL966272 | 0.85 | CALCA (0.47) | CALCAKDM4EHTTL3MBTL1MAPT | |
| SCHEMBL967705 | 0.84 | CALCA (0.51) | CALCAKDM4EHTTL3MBTL1MAPT | |
| SCHEMBL968040 | 0.84 | CALCA (0.62) | CALCAKDM4EL3MBTL1CDK1CDK4 | |
| SCHEMBL967790 | 0.84 | CALCA (0.53) | CALCAKDM4EHTTL3MBTL1POLB | |
| SCHEMBL965626 | 0.84 | CALCA (0.62) | CALCAKDM4EHTTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142365-A1 | Naphthyridine integrase inhibitors | GSK LLC | 2007-06-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142365-A1 | Naphthyridine integrase inhibitors | PCNA, SAMHD1, NTPCR | CALCA 4461/4885CTSB 1694/4885CACNA1B 4074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.