Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 7/20 | 0.39 |
| ▸ | F10 | P00742 | 7/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 6/20 | 0.38 |
| ▸ | F7 | P08709 | 6/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5563144 | 0.94 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL7040968 | 0.92 | KDM4E (0.66) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5568469 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5563827 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5563829 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5563311 | 0.80 | KDM4E (0.41) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL5569402 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5568600 | 0.78 | ALDH1A1 (0.42) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL5568417 | 0.78 | KDM4E (0.68) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL7650915 | 0.77 | KDM4E (0.59) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042288-B1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INST NAT SANTE RECH MED (FR) | 2007-11-07 | — | — | EP | disclosed |
| US-6335360-B1 | INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-01-01 | — | — | US | disclosed |
| EP-1042288-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033801-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1999-07-08 | — | — | WO | disclosed |