Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.74 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.74 |
| ▸ | RET | P07949 | 3/20 | 0.74 |
| ▸ | FLT3 | P36888 | 3/20 | 0.74 |
| ▸ | ABL1 | P00519 | 2/20 | 0.74 |
| ▸ | KDR | P35968 | 8/20 | 0.69 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.69 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.69 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.69 |
| ▸ | PLK4 | O00444 | 2/20 | 0.66 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.66 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.66 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19255670 | 0.90 | PDGFRB (0.77) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL5373629 | 0.89 | PDGFRB (0.76) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL5376617 | 0.88 | PDGFRB (0.74) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL31726848 | 0.88 | PDGFRB (0.74) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL31727096 | 0.88 | PDGFRB (0.74) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL5392303 | 0.88 | PDGFRB (0.74) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL13960772 | 0.88 | ALK (0.78) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL859965 | 0.86 | ALK (1.00) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL859966 | 0.86 | ALK (1.00) | ALKPDGFRBFGFR1RETFLT3 | |
| SCHEMBL8210235 | 0.86 | ALK (0.83) | ALKPDGFRBFGFR1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107709288-A | Phosphamide derivative and preparation method and application thereof | 四川海思科制药有限公司 | 2018-02-16 | — | — | CN | disclosed |
| EP-2635568-B1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECH CO LTD (CN) | 2017-08-16 | — | — | EP | disclosed |
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| US-8846953-B2 | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles | SCINOPHARM TAIWAN, LTD. (TW) | 2014-09-30 | — | — | US | disclosed |
| US-8846953-B2 | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles | SCINOPHARM TAIWAN, LTD. (TW) | 2014-09-30 | — | — | US | disclosed |
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM TAIWAN, LTD. (TW) | 2013-07-25 | — | — | US | disclosed |
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM TAIWAN, LTD. (TW) | 2013-07-25 | — | — | US | disclosed |
| WO-2012058780-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SKP2, SDHA, MDH2 | ALK 530/4885PDGFRB 285/4885FGFR1 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.