Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28281927 | 0.93 | CYP2C19 (0.46) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| Hydrochloric Acid SCHEMBL4137653 | 0.92 | TSHR (0.60) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| SCHEMBL83915 | 0.92 | TSHR (0.60) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| Ammonia Solution, Strong SCHEMBL10868076 | 0.89 | TSHR (0.57) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| Ammonia Solution, Strong SCHEMBL10870096 | 0.89 | TSHR (0.57) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| SCHEMBL28478983 | 0.89 | TSHR (0.57) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| SCHEMBL6739451 | 0.89 | TSHR (0.57) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| SCHEMBL8844260 | 0.89 | TSHR (0.57) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| Water SCHEMBL14109455 | 0.86 | TSHR (0.55) | CYP2C19HIF1ATSHRCYP2D6HMGCR | |
| SCHEMBL8363582 | 0.85 | EGLN1 (0.44) | CYP2C19HIF1ATSHRCYP2D6HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474388-B2 | ASTAXANTHIN ESTERS | DSM IP ASSETS BV (NL) | 2013-03-06 | — | — | EP | claimed |
| EP-1474388-B1 | ASTAXANTHIN ESTERS | DSM IP ASSETS BV (NL) | 2007-11-28 | — | — | EP | claimed |
| EP-1474388-A1 | ASTAXANTHIN ESTERS | DSM IP Assets B.V. (NL) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066583-A1 | ASTAXANTHIN ESTERS | DSM IP ASSETS B.V. (NL) | 2003-08-14 | — | — | WO | disclosed |