Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
| ▸ | DUT | P33316 | 2/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309171 | 0.84 | CRHR1 (0.44) | CRHR1PDE10A | |
| SCHEMBL5569011 | 0.82 | GRM5 (0.38) | GRM5MAPK1CRHR1FFAR1PDE10A | |
| SCHEMBL5568930 | 0.81 | CRHR1 (0.43) | GRM5CRHR1FFAR1 | |
| SCHEMBL5572240 | 0.80 | GRM5 (0.40) | GRM5MAPK1CRHR1FFAR1PDE10A | |
| SCHEMBL3260975 | 0.79 | CRHR1 (0.44) | CRHR1PDE10A | |
| SCHEMBL5571878 | 0.79 | CRHR1 (0.42) | GRM5CRHR1FFAR1 | |
| SCHEMBL5572225 | 0.77 | GRM5 (0.38) | GRM5MAPK1CRHR1FFAR1PDE10A | |
| SCHEMBL5567939 | 0.77 | CRHR1 (0.44) | GRM5CRHR1FFAR1 | |
| SCHEMBL5572219 | 0.72 | GRM5 (0.40) | GRM5MAPK1CRHR1FFAR1PDE10A | |
| SCHEMBL5571400 | 0.71 | JMJD6 (0.43) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | CRHR1, CRHR2, CRH | GRM5 239/4885MAPK1 757/4885CRHR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.