Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568502 | 1.00 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2HCRTR1KDM1A | |
| SCHEMBL5567648 | 0.84 | POLB (0.51) | TAS1R3TAS1R1KDM1AKMT2AMEN1 | |
| SCHEMBL5567651 | 0.84 | POLB (0.51) | TAS1R3TAS1R1KDM1AKMT2AMEN1 | |
| SCHEMBL7402512 | 0.84 | MCHR1 (0.52) | TAS1R3TAS1R1KDM1AKMT2APDE4B | |
| SCHEMBL7402511 | 0.84 | MCHR1 (0.52) | TAS1R3TAS1R1KDM1AKMT2APDE4B | |
| SCHEMBL5053376 | 0.82 | TAS1R3 (0.51) | TAS1R3TAS1R1KDM1AKMT2APDE4B | |
| SCHEMBL5737318 | 0.82 | TAS1R3 (0.51) | TAS1R3TAS1R1KDM1AKMT2APDE4B | |
| SCHEMBL7204083 | 0.82 | TAS1R3 (0.51) | TAS1R3TAS1R1KDM1AKMT2APDE4B | |
| SCHEMBL5046814 | 0.81 | KMT2A (0.52) | TAS1R3TAS1R1KDM1ACCR2KMT2A | |
| SCHEMBL5046817 | 0.81 | KMT2A (0.52) | TAS1R3TAS1R1KDM1ACCR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163226-B1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2007-03-14 | — | — | EP | disclosed |
| US-6534518-B1 | Phosphodiesterase inhibitors for respiratory system disorders | ALTANA PHARMA AG (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1163226-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000042018-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |