Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567651 | 1.00 | POLB (0.51) | POLBMAPK1OPRK1TDP1TAS1R3 | |
| SCHEMBL7237706 | 0.90 | TAS1R3 (0.42) | POLBMAPK1OPRK1TDP1TAS1R3 | |
| SCHEMBL7237703 | 0.90 | TAS1R3 (0.42) | POLBMAPK1OPRK1TDP1TAS1R3 | |
| SCHEMBL7415429 | 0.87 | ALDH1A1 (0.47) | MAPK1TAS1R3TAS1R1KDM1AMEN1 | |
| SCHEMBL7415428 | 0.87 | ALDH1A1 (0.47) | MAPK1TAS1R3TAS1R1KDM1AMEN1 | |
| SCHEMBL7204083 | 0.86 | TAS1R3 (0.51) | TAS1R3TAS1R1KDM1AMEN1KMT2A | |
| SCHEMBL5737318 | 0.86 | TAS1R3 (0.51) | TAS1R3TAS1R1KDM1AMEN1KMT2A | |
| SCHEMBL5053376 | 0.86 | TAS1R3 (0.51) | TAS1R3TAS1R1KDM1AMEN1KMT2A | |
| SCHEMBL5734935 | 0.85 | PDE4D (0.58) | — | |
| SCHEMBL7402512 | 0.85 | MCHR1 (0.52) | TAS1R3TAS1R1KDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163226-B1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2007-03-14 | — | — | EP | disclosed |
| US-6534518-B1 | Phosphodiesterase inhibitors for respiratory system disorders | ALTANA PHARMA AG (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1163226-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000042018-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |