Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877488 | 0.83 | KDM4E (0.50) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL27849216 | 0.82 | KDM4E (0.43) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL24611526 | 0.79 | MAPT (0.56) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL27575569 | 0.79 | MAPT (0.40) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL1670982 | 0.76 | BCAT2 (0.72) | ALDH1A1TSHRBCAT2MEN1KMT2A | |
| SCHEMBL361451 | 0.75 | KDM4E (0.44) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL16429514 | 0.74 | KDM4E (0.54) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL1823757 | 0.74 | GPR35 (0.52) | KDM4EMAPTALDH1A1GAAHPGD | |
| Acetic Acid SCHEMBL367778 | 0.74 | KDM4E (0.45) | KDM4EMAPTALDH1A1GAAHPGD | |
| Hydrochloric Acid SCHEMBL1825977 | 0.73 | GPR35 (0.51) | KDM4EMAPTALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023074408-A1 | THIOPHENE COMPOUND, METHOD FOR SYNTHESIZING SAME, AND COMPOSITION CONTAINING SAID THIOPHENE COMPOUND | 四国化成工業株式会社 | 2023-05-04 | — | — | WO | disclosed |
| EP-1819719-A2 | OLIGONUCLEOTIDE PROBES | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006051397-A2 | OLIGONUCLEOTIDE PROBES | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2006-05-18 | — | — | WO | disclosed |
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| CN-1158121-A | Indolizine sPLA2Inhibitors | LILLY CO ELI (US) | 1997-08-27 | — | — | CN | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |