Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 20/20 | 0.58 |
| ▸ | CTSS | P25774 | 17/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.58 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3601032 | 0.86 | CTSL (0.63) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL3603514 | 0.77 | CTSL (0.68) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL3591605 | 0.76 | CTSL (0.81) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL5567274 | 0.75 | CTSL (0.85) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL3604323 | 0.73 | CTSL (1.00) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL3599719 | 0.73 | CTSL (0.62) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL3585874 | 0.72 | CTSL (0.57) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL3594594 | 0.70 | CTSL (0.56) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL3594598 | 0.70 | CTSL (0.53) | CTSLCTSSKCNH2CTSK | |
| SCHEMBL5568564 | 0.70 | CTSL (0.58) | CTSLCTSSKCNH2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781623-A1 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS | Novartis AG (CH) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018284-A1 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS | NOVARTIS AG (CH) | 2006-02-23 | — | — | WO | disclosed |