Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567945 | 0.93 | CRHR1 (0.42) | CRHR1KDM4EHSD17B10GRM5SLC34A1 | |
| SCHEMBL5571864 | 0.92 | CRHR1 (0.43) | CRHR1GRM5KCNH2 | |
| SCHEMBL5568292 | 0.86 | CRHR1 (0.46) | CRHR1NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL5571878 | 0.85 | CRHR1 (0.42) | CRHR1KDM4EHSD17B10NPSR1MEN1 | |
| SCHEMBL5551912 | 0.82 | CRHR1 (0.51) | CRHR1KDM4EHSD17B10NPSR1 | |
| SCHEMBL5569019 | 0.79 | CRHR1 (0.46) | CRHR1KDM4EHSD17B10GRM5SLC34A1 | |
| SCHEMBL2191943 | 0.79 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL5572490 | 0.78 | CRHR1 (0.46) | CRHR1GRM5SLC34A1KCNH2 | |
| SCHEMBL5568930 | 0.78 | CRHR1 (0.43) | CRHR1KDM4EHSD17B10GRM5 | |
| SCHEMBL5568978 | 0.77 | CRHR1 (0.45) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | CRHR1, CRHR2, CRH | CRHR1 1/4885NPC1 1106/4885ALDH1A1 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.