Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RHOC | P08134 | 2/20 | 0.50 |
| ▸ | RHOA | P61586 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567044 | 0.86 | RAB9A (0.61) | POLBALDH1A1RAB9ACYP1A2TSHR | |
| SCHEMBL5569181 | 0.79 | POLB (0.55) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL5566675 | 0.78 | POLB (0.57) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL5569234 | 0.78 | POLB (0.55) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL5570403 | 0.77 | ALDH1A1 (0.54) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL5569176 | 0.77 | POLB (0.53) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL5566055 | 0.73 | ALDH1A1 (0.52) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL5629014 | 0.69 | POLB (0.55) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL16527695 | 0.67 | IDO1 (0.54) | POLBALDH1A1RHOCRHOARAB9A | |
| SCHEMBL16542660 | 0.67 | IDO1 (0.60) | POLBALDH1A1RHOCRHOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250415-B2 | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-31 | — | — | US | disclosed |