Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.40 |
| ▸ | USP2 | O75604 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550636 | 0.90 | CHRM3 (0.42) | HSD11B1CHRM3CYP3A4CYP2C19USP2 | |
| SCHEMBL550166 | 0.90 | CHRM3 (0.42) | HSD11B1CHRM3CYP3A4CYP2C19USP2 | |
| SCHEMBL550328 | 0.90 | CHRM3 (0.42) | HSD11B1CHRM3CYP3A4CYP2C19USP2 | |
| SCHEMBL5571628 | 0.88 | HSD11B1 (0.42) | HSD11B1CHRM3HRH3 | |
| SCHEMBL550322 | 0.88 | CYP3A4 (0.41) | HSD11B1CHRM3CYP3A4CYP2C19USP2 | |
| SCHEMBL550321 | 0.88 | CYP3A4 (0.41) | HSD11B1CHRM3CYP3A4CYP2C19USP2 | |
| SCHEMBL550765 | 0.85 | HSD11B1 (0.40) | HSD11B1CYP2C19ALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL2699416 | 0.85 | HSD11B1 (0.40) | HSD11B1CYP2C19ALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL2700977 | 0.84 | ALDH1A1 (0.41) | HSD11B1CYP3A4CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL3705343 | 0.84 | ALDH1A1 (0.41) | HSD11B1CYP3A4CYP2C19ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |