Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532109 | 0.93 | S1PR4 (0.49) | S1PR4PTGDR2KDM4EPKMHTT | |
| SCHEMBL7018653 | 0.79 | S1PR4 (0.52) | S1PR4KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5569556 | 0.78 | S1PR4 (0.47) | S1PR4KDM4EHTTTDP1GAA | |
| SCHEMBL16742593 | 0.77 | KDM4E (0.51) | S1PR4PTGDR2KDM4EPKMHTT | |
| SCHEMBL5533491 | 0.77 | ALDH1A1 (0.47) | S1PR4KDM4EPKMTDP1GAA | |
| SCHEMBL218258 | 0.76 | — | — | |
| SCHEMBL16742921 | 0.74 | KDM4E (0.66) | S1PR4PTGDR2KDM4EPKMHTT | |
| SCHEMBL3710075 | 0.74 | PTGDR2 (0.49) | S1PR4PTGDR2KDM4EPKMHTT | |
| SCHEMBL3781153 | 0.73 | KDM4E (0.53) | PTGDR2KDM4EPKMHTTTDP1 | |
| SCHEMBL1367786 | 0.71 | PTGDR2 (0.45) | PTGDR2KDM4EPKMHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799658-A2 | MODULATORS OF CRTH2 REZEPTOR ACTIVITY FOR THE TREATMENT OF PROSTAGLANDIN D2 MEDIATED DISEASES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006037982-A2 | MODULATORS OF CRTH2 RECEPTOR ACTIVITY FOR THE TREATMENT OF PROSTAGLANDIN D2 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |