⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598070 | 0.86 | — | — | |
| SCHEMBL1721038 | 0.84 | — | — | |
| SCHEMBL9687572 | 0.83 | — | — | |
| SCHEMBL1919608 | 0.77 | — | — | |
| SCHEMBL7396041 | 0.75 | — | — | |
| SCHEMBL611093 | 0.72 | — | — | |
| SCHEMBL3646780 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL3651701 | 0.70 | — | — | |
| SCHEMBL2599072 | 0.69 | — | — | |
| SCHEMBL7383347 | 0.66 | DRD2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841738-A2 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | Athersys, Inc. (US) | 2007-10-10 | — | — | EP | claimed |
| WO-2007081299-A2 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ATHERSYS, INC. (US) | 2007-07-19 | — | — | WO | claimed |
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | claimed |
| EP-0422134-A4 | 5-HT SELECTIVE AGENTS | — | 1992-05-06 | — | — | EP | claimed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | claimed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | claimed |
| EP-1841738-A2 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | Athersys, Inc. (US) | 2007-10-10 | — | — | EP | disclosed |
| WO-2007081299-A2 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ATHERSYS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |
| US-20060025601-A1 | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators | ATHERSYS, INC. | 2006-02-02 | — | — | US | disclosed |
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | disclosed |
| WO-1993008166-A1 | BENZO-ISOQUINOLINE DERIVATIVES AND ANALOGS AND THEIR USE IN THERAPEUTICS | THE UPJOHN COMPANY (US) | 1993-04-29 | — | — | WO | disclosed |
| EP-0539209-A1 | Benzo-isoquinoline derivatives and analogs and their use in therapeutics | THE UPJOHN COMPANY (US) | 1993-04-28 | — | — | EP | disclosed |
| EP-0422134-A4 | 5-HT SELECTIVE AGENTS | — | 1992-05-06 | — | — | EP | disclosed |
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4282246-A | Antidiabetic furancarboxylic and thiphenecarboxylic acids | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |