Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149220 | 0.93 | ROCK2 (0.36) | ROCK2SMN1; SMN2ABCB1DRD1ALOX15 | |
| SCHEMBL5573142 | 0.85 | CA1 (0.36) | DRD1TSHR | |
| SCHEMBL5569818 | 0.85 | SMN1; SMN2 (0.34) | ROCK2SMN1; SMN2ABCB1DRD1TSHR | |
| SCHEMBL4443108 | 0.85 | SMN1; SMN2 (0.34) | ROCK2SMN1; SMN2ABCB1DRD1TSHR | |
| SCHEMBL5897015 | 0.83 | ABCB1 (0.40) | ROCK2SMN1; SMN2ABCB1 | |
| SCHEMBL30217868 | 0.83 | ABCB1 (0.40) | ROCK2SMN1; SMN2ABCB1 | |
| SCHEMBL5569955 | 0.82 | POLB (0.33) | POLBABCB1 | |
| SCHEMBL4454435 | 0.82 | SMN1; SMN2 (0.35) | POLBSMN1; SMN2ABCB1TSHR | |
| SCHEMBL9177307 | 0.81 | POLL (0.39) | ROCK2SMN1; SMN2ABCB1ALOX15TSHR | |
| SCHEMBL5674190 | 0.78 | POLL (0.39) | ABCB1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761548-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006002729-A1 | PROCESS FOR THE PREPARATION OF ASYMMETRICALLY SUBSTITUTED BIARYLDIPHOSPHINES | LONZA AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| EP-1609795-A1 | Process for the preparation of asymmetrically substituted biaryldiphosphines | Lonza AG (CH) | 2005-12-28 | — | — | EP | disclosed |