Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5570147 | 1.00 | MEN1 (0.40) | MEN1KMT2AKDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL5628678 | 0.87 | KDM4E (0.35) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL14422269 | 0.86 | GSK3B (0.42) | NPC1RAB9ATRPM5TP53SMN1; SMN2 | |
| SCHEMBL14422270 | 0.83 | RAB9A (0.42) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL5571315 | 0.81 | TRPM5 (0.32) | TRPM5CLK1TGFBR1 | |
| SCHEMBL5571316 | 0.81 | PIM1 (0.34) | MEN1KMT2AKDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL5573751 | 0.80 | APP (0.36) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL5573752 | 0.80 | APP (0.36) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL5573825 | 0.78 | ELANE (0.40) | MEN1KMT2ATRPM5SMN1; SMN2ALDH1A1 | |
| SCHEMBL5573823 | 0.78 | ELANE (0.40) | MEN1KMT2ATRPM5SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101039944-B | 1,5-naphthyridine azolidinones having CDK1 antiproliferative activity | HOFFMANN LA ROCHE | 2010-05-05 | — | — | CN | claimed |
| CN-101039944-A | 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity | HOFFMANN LA ROCHE (CH) | 2007-09-19 | — | — | CN | claimed |
| EP-1805174-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-07-11 | — | — | EP | claimed |
| WO-2006040052-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | claimed |
| US-20060084673-A1 | 1,5-naphthyridine azolinone | LIU JIN-JUN | 2006-04-20 | — | — | US | claimed |
| CN-101039944-B | 1,5-naphthyridine azolidinones having CDK1 antiproliferative activity | HOFFMANN LA ROCHE | 2010-05-05 | — | — | CN | disclosed |
| CN-101039944-A | 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity | HOFFMANN LA ROCHE (CH) | 2007-09-19 | — | — | CN | disclosed |
| US-7268231-B2 | 1,5-Naphthyridine azolinone | HOFFMANN-LA ROCHE INC. (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1805174-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006040052-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | disclosed |
| US-20060084673-A1 | 1,5-naphthyridine azolinone | LIU JIN-JUN | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084673-A1 | 1,5-naphthyridine azolinone | CDK1, CDK15, CDK14 | MEN1 1183/4885KMT2A 2233/4885KDM4E 1444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.