Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573053 | 0.84 | TP53 (0.46) | TP53MDM2MAPTGAAKDM4E | |
| SCHEMBL5573049 | 0.78 | TP53 (0.51) | TP53MDM2OPRM1 | |
| SCHEMBL4912373 | 0.77 | TP53 (1.00) | TP53MDM2 | |
| SCHEMBL4912370 | 0.77 | TP53 (1.00) | TP53MDM2 | |
| SCHEMBL18569316 | 0.73 | MDM2 (0.87) | TP53MDM2 | |
| SCHEMBL12085950 | 0.72 | MDM2 (0.91) | TP53MDM2 | |
| SCHEMBL5570570 | 0.72 | TP53 (0.58) | TP53MDM2OPRM1 | |
| SCHEMBL1821968 | 0.70 | MDM2 (1.00) | TP53MDM2 | |
| SCHEMBL29994301 | 0.70 | MDM2 (1.00) | TP53MDM2 | |
| SCHEMBL4914484 | 0.69 | MDM2 (1.00) | TP53MDM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |