Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 12/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 12/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5570568 | 0.78 | TP53 (0.62) | TP53MDM2OPRM1 | |
| SCHEMBL4914450 | 0.76 | TP53 (0.80) | TP53MDM2 | |
| SCHEMBL4914455 | 0.76 | TP53 (0.80) | TP53MDM2 | |
| SCHEMBL18569134 | 0.76 | TP53 (0.64) | TP53MDM2 | |
| SCHEMBL5573118 | 0.69 | TP53 (0.35) | TP53MDM2OPRM1 | |
| SCHEMBL4907760 | 0.69 | MDM2 (0.82) | TP53MDM2 | |
| SCHEMBL4907765 | 0.69 | MDM2 (0.82) | TP53MDM2 | |
| SCHEMBL5573072 | 0.68 | OPRM1 (0.51) | MDM2OPRM1 | |
| SCHEMBL5570570 | 0.68 | TP53 (0.58) | TP53MDM2OPRM1 | |
| SCHEMBL5570564 | 0.67 | TP53 (0.40) | TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |