Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LCAT | P04180 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154561 | 0.81 | CHRNB2 (0.54) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL20070653 | 0.80 | CHRNB2 (0.53) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL2702630 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL549800 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL2702628 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL549801 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL550891 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL550890 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL20148753 | 0.78 | CHRNB2 (0.51) | CHRNB2CHRNA4RETKCNJ1KCNH2 | |
| SCHEMBL5568522 | 0.77 | CYP3A4 (0.41) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |