Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 16/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.40 |
| ▸ | USP2 | O75604 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569058 | 0.82 | MEN1 (0.49) | CYP3A4HIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL5572058 | 0.77 | CHRNB2 (0.47) | CYP3A4HIF1ATSHRCYP2C19USP2 | |
| SCHEMBL5572077 | 0.76 | CYP3A4 (0.41) | CYP3A4HIF1ATSHRCYP2C19USP2 | |
| SCHEMBL550343 | 0.74 | HSD11B1 (0.40) | USP2ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL550344 | 0.74 | HSD11B1 (0.40) | USP2ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL22466178 | 0.74 | ALDH1A1 (0.48) | CYP3A4HIF1ATSHRCYP2C19USP2 | |
| SCHEMBL5572743 | 0.73 | RET (0.46) | CYP3A4TSHRCYP2C19USP2ALDH1A1 | |
| SCHEMBL5571645 | 0.72 | CYP2D6 (0.42) | CYP3A4HIF1ATSHRCYP2C19USP2 | |
| SCHEMBL5569044 | 0.72 | CYP2D6 (0.42) | CYP3A4HIF1ATSHRCYP2C19ALDH1A1 | |
| SCHEMBL5572387 | 0.72 | CYP2D6 (0.42) | CYP3A4HIF1ATSHRCYP2C19USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |