Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 5/20 | 0.61 |
| ▸ | HTR2A | P28223 | 5/20 | 0.61 |
| ▸ | HTR7 | P34969 | 4/20 | 0.61 |
| ▸ | DRD3 | P35462 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 3/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.61 |
| ▸ | DRD1 | P21728 | 3/20 | 0.61 |
| ▸ | DRD5 | P21918 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27715352 | 0.94 | KCNH2 (0.74) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL10053231 | 0.90 | KCNH2 (0.64) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL26108725 | 0.89 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL26107525 | 0.89 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL4519313 | 0.89 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL18301485 | 0.88 | KCNH2 (0.69) | KCNH2POLBHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL26108256 | 0.87 | KCNH2 (0.83) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL13711971 | 0.87 | KCNH2 (0.71) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL28898801 | 0.86 | KCNH2 (0.59) | KCNH2POLBHTR1ADRD2HTR2A | |
| SCHEMBL9310190 | 0.86 | KCNH2 (0.56) | KCNH2POLBHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61167682-A | — | — | None | — | — | JP | disclosed |
| EP-1863809-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20070238727-A1 | 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals | TIBOTEC BVBA (BE) | 2007-10-11 | — | — | US | disclosed |
| US-20070238727-A1 | 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals | TIBOTEC BVBA (BE) | 2007-10-11 | — | — | US | disclosed |
| WO-2006107753-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |
| US-4619930-A | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use | BRISTOL-MYERS COMPANY (US) | 1986-10-28 | — | — | US | disclosed |
| JP-S61167682-A | ANTIPSYCHOTIC CYCLIC IMIDE DERIVATIVE OF 2-(4-BUTYLPIPERAZINE-1-YL)PYRIDINES | BRISTOL MYERS CO | 1986-07-29 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238727-A1 | 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals | NR5A2, NR5A1, NR4A1 | KCNH2 2260/4885POLB 1490/4885HTR1A 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.