Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | DRD4 | P21917 | 4/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | DRD5 | P21918 | 2/20 | 0.57 |
| ▸ | HRH1 | P35367 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28898801 | 0.95 | KCNH2 (0.59) | KCNH2POLBKDM4EALDH1A1MAPT | |
| Propylamine SCHEMBL28972661 | 0.94 | KCNH2 (0.58) | KCNH2POLBKDM4EALDH1A1MAPT | |
| SCHEMBL5572065 | 0.90 | KCNH2 (0.69) | KCNH2POLBHTR1ADRD2DRD4 | |
| SCHEMBL13711971 | 0.90 | KCNH2 (0.71) | KCNH2POLBALDH1A1HTR1ADRD2 | |
| SCHEMBL27715352 | 0.88 | KCNH2 (0.74) | KCNH2POLBHTR1ADRD2DRD4 | |
| SCHEMBL18301489 | 0.87 | KCNH2 (0.64) | KCNH2POLBKDM4EALDH1A1HTR1A | |
| SCHEMBL3867807 | 0.86 | KDM4E (0.64) | KCNH2POLBKDM4EALDH1A1MAPT | |
| SCHEMBL4519313 | 0.85 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2DRD4 | |
| SCHEMBL26108725 | 0.85 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2DRD4 | |
| SCHEMBL26107525 | 0.85 | KCNH2 (0.85) | KCNH2POLBHTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370340-B2 | HIV replication inhibiting pyrimidines | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-06 | — | — | US | disclosed |
| EP-1921077-B1 | AGENT FOR TREATING AND/OR PREVENTING SLEEP DISORDER | KYOWA HAKKO KIRIN CO LTD (JP) | 2017-07-26 | — | — | EP | disclosed |
| US-8106031-B2 | Hydrolytically-resistant boron-containing therapeutics and methods of use | ANACOR PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370340-B2 | HIV replication inhibiting pyrimidines | RRM2B, CCNO, RRM2 | KCNH2 1547/4885POLB 50/4885KDM4E 2092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.