Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.43 |
| ▸ | IDH2 | P48735 | 7/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27724207 | 0.81 | BACE1 (0.79) | BACE1ADORA2AKDM4EUSP2ALDH1A1 | |
| SCHEMBL4055219 | 0.80 | TMIGD3 (0.53) | BACE1TMIGD3ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5431285 | 0.80 | PTGDR2 (0.70) | PTGDR2SLC6A9 | |
| SCHEMBL16875842 | 0.76 | CFTR (0.55) | KDM4EIDH2 | |
| SCHEMBL1094881 | 0.76 | BACE1 (0.53) | BACE1KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL16875837 | 0.75 | KDM4E (0.50) | KDM4EUSP2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL27703302 | 0.74 | PELI1 (0.50) | TMIGD3ADORA2AIDH2 | |
| SCHEMBL5572639 | 0.73 | ALDH1A1 (0.49) | BACE1KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL24436827 | 0.72 | KDM4E (0.62) | BACE1KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL4981997 | 0.72 | KDM4E (0.62) | BACE1KDM4EUSP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799658-A2 | MODULATORS OF CRTH2 REZEPTOR ACTIVITY FOR THE TREATMENT OF PROSTAGLANDIN D2 MEDIATED DISEASES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006037982-A2 | MODULATORS OF CRTH2 RECEPTOR ACTIVITY FOR THE TREATMENT OF PROSTAGLANDIN D2 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |