Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830673 | 0.86 | CNR1 (0.41) | TMIGD3ADORA2ACNR1SLC6A9PTGDR2 | |
| SCHEMBL5764049 | 0.82 | BACE1 (0.54) | BACE1PTGDR2NR1H4CFDAMY1A | |
| SCHEMBL5572529 | 0.80 | BACE1 (0.53) | TMIGD3ADORA2ABACE1SLC6A9PTGDR2 | |
| SCHEMBL24574845 | 0.74 | SLC6A9 (0.47) | TMIGD3ADORA2ASLC6A9CFDKMT2A | |
| SCHEMBL5763924 | 0.74 | PTGDR2 (0.49) | BACE1PTGDR2CFDAMY1AALDH1A1 | |
| SCHEMBL1690266 | 0.73 | PTGDR2 (0.42) | BACE1PTGDR2NR1H4CFDAMY1A | |
| SCHEMBL11338058 | 0.72 | KDM4E (0.58) | NR1H4CFDAMY1AABCB11ALDH1A1 | |
| SCHEMBL28179635 | 0.72 | CYP2A6 (0.42) | CNR1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL3691064 | 0.72 | KMT2A (0.61) | NR1H4CFDABCB11ALDH1A1HPGD | |
| SCHEMBL5004411 | 0.72 | CNR1 (0.42) | TMIGD3ADORA2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |