Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 14/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306365 | 0.92 | CYP2C9 (0.47) | CYP2C9CCR2KCNH2MEP1BCYP3A4 | |
| SCHEMBL306010 | 0.90 | CYP2C9 (0.46) | CYP2C9CCR2KCNH2MEP1BCYP3A4 | |
| SCHEMBL304863 | 0.89 | GPR27 (0.48) | CYP2C9CCR2KCNH2 | |
| SCHEMBL129215 | 0.87 | POLB (0.44) | CYP2C9CCR2KCNH2CYP3A4 | |
| SCHEMBL305791 | 0.87 | CYP2C9 (0.44) | CYP2C9CCR2KCNH2CYP3A4 | |
| SCHEMBL306222 | 0.87 | CYP2C9 (0.44) | CYP2C9CCR2KCNH2MEP1BCYP3A4 | |
| SCHEMBL305782 | 0.87 | CCR2 (0.42) | CYP2C9CCR2CYP3A4TRPM8 | |
| SCHEMBL305134 | 0.86 | CYP2C9 (0.41) | CYP2C9CCR2CYP3A4 | |
| SCHEMBL307342 | 0.84 | CCR2 (0.42) | CYP2C9CCR2KCNH2CYP3A4 | |
| SCHEMBL126997 | 0.81 | CYP2C9 (0.66) | CYP2C9CCR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-A2 | HETEROARYL SULFONAMIDES AND CCR2 | ChemoCentryx Inc (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006076644-A2 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX, INC. (US) | 2006-07-20 | — | — | WO | disclosed |