Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5982035 | 0.92 | TUBB4A (0.60) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6192534 | 0.81 | TUBB4A (0.54) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5573030 | 0.79 | TUBB4A (0.65) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4019994 | 0.79 | PDE4A (0.61) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3851419 | 0.78 | TUBB4A (0.69) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6087982 | 0.78 | POLB (0.57) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3151543 | 0.76 | TUBB4A (0.82) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30641123 | 0.76 | CNR2 (0.67) | POLBCNR2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6087363 | 0.76 | POLB (0.56) | POLBTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28516015 | 0.75 | TUBB4A (0.65) | POLBTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205299-B2 | Indole derivatives having an apoptosis-inducing effect | ZENTARIS GMBH (DE) | 2007-04-17 | — | — | US | disclosed |
| EP-1595878-A1 | INDOLE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY | Zentaris GmbH (DE) | 2005-11-16 | — | — | EP | disclosed |
| US-20040266762-A1 | Indole derivatives having an apoptosis-inducing effect | AETERNA ZENTARIS GMBH (DE) | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266762-A1 | Indole derivatives having an apoptosis-inducing effect | BAD, API5, AIFM1 | POLB 4407/4885TUBB4A 1171/4885TUBB 1105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.