SCHEMBL5573138

SCHEMBL5573138

Fc1cccc(CN=C=S)c1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 12/20 0.49
TRPA1 O75762 3/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP3A4 P08684 1/20 0.44
HPGD P15428 1/20 0.44
GABRA1 P14867 1/20 0.36
GABRB2 P47870 1/20 0.36
AKR1B1 P15121 1/20 0.35
CYP2E1 P05181 1/20 0.33
CYP2A6 P11509 1/20 0.33
HIF1A Q16665 1/20 0.33
CYP2A13 Q16696 1/20 0.33
EPAS1 Q99814 1/20 0.33
RIPK1 Q13546 1/20 0.33
TAAR1 Q96RJ0 1/20 0.32
CES2 O00748 1/20 0.31
BCHE P06276 1/20 0.31
CES1 P23141 1/20 0.31
MPO P05164 1/20 0.31
IDO1 P14902 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3933178 0.84 MIF (0.52) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL2947684 0.81 MIF (0.46) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL1648245 0.81 RIPK1 (0.39) ALDH1A1CYP3A4GABRA1GABRB2AKR1B1
SCHEMBL2109303 0.78 MIF (0.53) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL29616337 0.77 MIF (0.62) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL2141390 0.77 MIF (0.62) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL5541658 0.74 CES2 (0.39) AKR1B1RIPK1TAAR1CES2BCHE
SCHEMBL3482870 0.74 RIPK1 (0.38) AKR1B1RIPK1TAAR1CES2BCHE
SCHEMBL9715358 0.72 MIF (0.52) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL8763355 0.71 MIF (0.56) MIFTRPA1ALDH1A1CYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1841320-A2 METHODS AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING PSORIASIS S.U.L.V.E. Ltd. (IL) 2007-10-10 EP disclosed
WO-2006075330-A2 METHODS AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING PSORIASIS S.U.L.V.E. LTD. (IL) 2006-07-20 WO disclosed