Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5571405 | 0.81 | KDM4E (0.43) | MAPTHPGDALDH1A1CYP1A2MEN1 | |
| SCHEMBL4776998 | 0.79 | MAPT (0.45) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL5272473 | 0.79 | MAPT (0.46) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL5266914 | 0.78 | MAPT (0.41) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL4780471 | 0.77 | MAPT (0.45) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL5573980 | 0.77 | MAPT (0.40) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL5269908 | 0.77 | ALDH1A1 (0.44) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL4777292 | 0.76 | MAPT (0.43) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL5571402 | 0.75 | KDM4E (0.43) | MAPTHPGDALDH1A1CYP1A2XBP1 | |
| SCHEMBL5512949 | 0.75 | MAPT (0.46) | MAPTHPGDALDH1A1CYP1A2XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841736-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077367-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |