Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533962 | 0.82 | REN (0.40) | RENKCNH2DPP4 | |
| SCHEMBL534057 | 0.73 | REN (0.58) | RENKCNH2DPP4 | |
| SCHEMBL535144 | 0.71 | REN (0.74) | RENKCNH2 | |
| SCHEMBL557684 | 0.70 | REN (0.61) | RENKCNH2 | |
| SCHEMBL556463 | 0.69 | REN (0.58) | RENKCNH2HIF1A | |
| SCHEMBL556618 | 0.69 | REN (0.75) | RENKCNH2 | |
| SCHEMBL23291648 | 0.69 | ROCK1 (0.40) | USP30ROCK1HIF1A | |
| SCHEMBL23291570 | 0.69 | ROCK1 (0.40) | USP30ROCK1HIF1A | |
| SCHEMBL20211266 | 0.68 | AAK1 (0.41) | USP30ROCK1 | |
| SCHEMBL586426 | 0.68 | HIF1A (0.42) | KCNH2USP30ROCK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | REN 1/4885KCNH2 1198/4885USP30 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.