Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 9/20 | 0.76 |
| ▸ | GRIN3B | O60391 | 9/20 | 0.76 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.76 |
| ▸ | GRIN2A | Q12879 | 9/20 | 0.76 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.76 |
| ▸ | GRIN2C | Q14957 | 9/20 | 0.76 |
| ▸ | GRIN3A | Q8TCU5 | 9/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.76 |
| ▸ | APAF1 | O14727 | 1/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | MMP2 | P08253 | 1/20 | 0.76 |
| ▸ | RAD52 | P43351 | 1/20 | 0.76 |
| ▸ | CASP6 | P55212 | 1/20 | 0.76 |
| ▸ | UBE2N | P61088 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | FURIN | P09958 | 2/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914608 | 0.87 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29750405 | 0.79 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL13940984 | 0.77 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL5703072 | 0.75 | ASIC1 (0.81) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Nitric Acid SCHEMBL5575099 | 0.72 | MEN1 (0.53) | MEN1PSMD14APAF1USP2POLB | |
| Nitric Acid SCHEMBL5575095 | 0.72 | MEN1 (0.53) | MEN1PSMD14APAF1USP2POLB | |
| SCHEMBL7715576 | 0.72 | GRIN2D (0.68) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7715572 | 0.72 | GRIN2D (0.68) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7715574 | 0.72 | GRIN2D (0.68) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL14197990 | 0.72 | GRIN2D (0.70) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1766365-A2 | DETECTION OF ANALYTES | Platypus Technologies, LLC (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20070004046-A1 | Detection of analytes | PLATYPUS TECHNOLOGIES, LLC (US) | 2007-01-04 | — | — | US | disclosed |
| WO-2006085971-A2 | DETECTION OF ANALYTES | PLATYPUS TECHNOLOGIES, LLC (US) | 2006-08-17 | — | — | WO | disclosed |